CLIMARA® (estradiol transdermal system) is the leading transdermal (patch) form of estrogen replacement. The CLIMARA® system delivers estrogen directly into the blood stream in the same manner as when it is naturally produced in a woman's body. CLIMARA® was the first once-a-week transdermal form of estrogen replacement therapy and has increased its lead over the rest of the market by adding to its list of firsts. CLIMARA® was the first and only once-a-week ERT in four strengths, the first and only once-a week ERT indicated for prevention of osteoporosis, and the lowest estrogen dose clinically proven to prevent osteoporosis.